02 Oct 2019

Acute-Phase proteins differ in mice with and without prostate inflammation

L. Hao et al conducted a quantitative

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02 Oct 2019

L. Hao et al conducted a quantitative proteomic analysis on induced prostate inflammation in mice and published a paper in the American Journal of Physiology-Renal Physiology.

Researchers compared the quantitative proteomic analysis of urine from mice with and without prostate-specific inflammation. Researchers looked at prostate inflammation as it is a key symptom of many different prostate conditions, such as infection and cancer, and therefore by doing so one gains a better understanding of disease mechanisms.

Researchers induced prostate-specific inflammation by conditional prostate epithelial IL-1β expression. Next, they ran urine sample tests and quantified urinary proteins. L. Hao et al found that different levels of acute-phase response proteins (proteins which have plasma concentrations that increase or decrease in response to inflammation) were represented between mice with and without prostate inflammation; these were haptoglobin, inter-α-trypsin inhibitor, and α1-antitrypsin 1-1.

Researchers concluded that mass-spectrometry-based quantitative urinary proteomics is an important and powerful method for discovering biomarkers and uncovering molecular urological mechanisms.

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