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McKetney Publishes “Proteomic Atlas of the Human Brain in Alzheimer’s Disease”

Justin McKetney et. al. recently published a paper on neurodegenerative diseases of the brain, such as Alzheimer’s disease (AD). Using state-of-the-art mass spectrometry, the group identified a core brain proteome where substantial differences were identified between previous proteomic studies of mature adult brains and their aged cohort. These findings suggest considerable value in examining specifically the brain proteome of aged human populations and can serve as a guide for how specific regions of the brain are affected by aging and neurodegeneration.

Article selected for Journal of Biological Chemistry 2018 Collection

The Mitok/Coon/Attie article “Islet proteomics reveals genetic variation in dopamine production resulting in altered insulin secretion” was selected as the representative ‘Genomics and proteomics’ article for the Journal of Biological Chemistry 2018 Retrospective Collection called “The year in JBC: 2018.” When choosing the representative articles, the journal editors considered hundreds of papers to come up with what they felt best represented the exciting advances reported in JBC last year. This special issue can be found at

Coon Honored for Discovery in Proteomic Sciences

Joshua Coon, PhD, professor of biomolecular chemistry and chemistry has been awarded a Discovery in Proteomic Sciences Award from the Human Proteome Organization (HUPO).

HUPO is an international organization that represents and promotes proteomics through global cooperation and collaborations by fostering the development of new technologies, techniques and training.The award recognizes Prof. Coon’s outstanding effort and achievement in proteomics, the study of cellular proteins and their functions.

The Coon lab team develops and applies mass spectrometric technology to study human health and develop scientific instruments to measure molecules in living systems. Prof Coon has made significant contributions to proteomics and metabolomics research by developing next-generation instrumentation and methods, proteomics workflows, novel isotopic labeling quantitative approaches and associated software development. Coon’s work has influenced many labs in the United States and abroad, and the tools he has created are in use throughout the world.

Coon is the inaugural holder of the Thomas and Margaret Pyle Chair at UW-Madison and an affiliate of the Morgridge Institute for Research. He presently serves as director of the National Institute of General Medical Science funded National Center for Quantitative Biology of Complex Systems. He joined the UW-Madison faculty in 2005.

Dr. Shishkova’s article chosen by Springer Nature’s Change the World initiative for 2018

Dr. Shishkova’s article, titled “Gender Diversity in a STEM Subfield – Analyses of a Large Scientific Society and Its Annual Conferences,” was recently chosen by Springer Nature’s Change the World initiative for 2018. The article can be found listed under the ” Chemistry, Engineering, Physics & Materials” category.

The Change the World, One Article at a Time initiative selects scientific findings published in 2017 that can have an impact on society’s most pressing problems. Congratulations to Dr. Shishkova for this recognition!

Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys

Caloric restriction extends lifespan and delays aging in diverse species. On pp. 677–688 of the current issue of Cell Metabolism, Rhoads et al. integrated large-scale data from the hepatic transcriptome, proteome, and metabolome of rhesus monkeys after 2 years on a 30% calorie-restricted diet to reveal multi-modal mechanisms driven by calorie restriction to rewire metabolism. The panels of the cover image represent the four distinct regulatory strategies recruited by caloric restriction: transcriptional, post-transcriptional, translational, and post-translational, each of which gives a different “view” of the unified and integrated molecular response to caloric restriction.

1st Annual North American Mass Spectrometry Summer School

Please join us for our first annual mass spectrometry summer school. We are proud to have assembled over a dozen world leading experts in mass spectrometry for this four-day course. Our goal is to provide our students, both from academia and industry, an engaging and inspiring program covering the latest in the application of mass spectrometry to omic analyses. Tutorial lectures range from experimental design, sample preparation, and quantification to the basics of high performance mass analyzers and data analysis. Also planned are several hands-on workshops – aimed at both scientific and professional development. Finally, we will take a break on one afternoon for a whole group experience at nearby Devil’s Lake State Park where workshop goers can choose from a slate of exciting recreational activities. This workshop is made possible by generous funding from the National Science Foundation (Integrated Organismal Systems, Plant Genome Research Program, Grant No. 1546742) and the National Institutes of Health National Center for Quantitative Biology of Complex Systems (P41 GM108538). As such, there is no cost to participate and several travel awards are available.

Learn More

Register for Summer School

The ‘Ice Road Truckers of Science’ and Why We Need Them

Authors Rebecca Blank, chancellor of the University of Wisconsin-Madison, and Brad Schwartz, CEO of Morgridge Institute for Research in Madison, call for a scientific renaissance regarding American policy choices. Their article “The ‘Ice Road Truckers of science’ and why we need them”, featured in The Hill, reminisces on a time when American science dominated the world because of the US government’s commitment to funding basic research at a level higher than all other countries. That commitment made Nobel Prize winning discoveries possible and resulted in tremendous gains for the global community. Blank and Schwartz warn that if American policy choices continue to “sacrifice the opportunity to make [such] discoveries, then [America] will become one of the nations that must figure out how to make someone else’s inventions cheaper, instead of leading the market by capitalizing on new knowledge.”

Please read the article for yourself, here

John Syka Visit

On Tuesday, NCQBCS welcomed John Syka, the inventor of Quadrupole linear ion trap and co-inventor of ETD, to our lab. Syka toured our facilities, celebrated a graduate student’s thesis defense with the team, and delivered an exceptional tutorial on ion trapping for staff and students. John is a Research Scientist at Thermo Fisher Scientific and his visit importantly supports the ongoing collaboration between our organizations.

Evgenia Shishkova’s Thesis Defense

We proudly congratulate Dr. Evgenia Shishkova for her successfully Ph.D. Defense! Evgenia is the Coon Group’s 21st Ph.D. graduate and will be joining NCQBCS as a staff scientist in the New Year!