Mitochondria are central to many biochemical processes, therefore even moderate impairment could have drastic cellular consequences. To explore cellular strategies for surmounting mitochondrial stress, we conducted a series of chemical and genetic perturbations to Saccharomyces cerevisiae and analysed the cellular responses using deep multiomic mass spectrometry profiling. Collectively, this work reveals a key component of mitochondrial stress recovery and offers a rich resource for further exploration of the broad cellular responses to mitochondrial dysfunction.
Triacylglycerol mobilization underpins mitochondrial stress recovery