Designed and synthesized in-house, DiLeu isobaric tags are compact and offer excellent performance, often enhancing peptide backbone fragmentation. DiLeu-tagged peptides therefore can improve confidence in sequence identification all while generating reporter ions at strikingly high abundance. Besides providing a wide quantitative dynamic range, the reporter ion signal affords improved multiplexing capacity, as the overall ion population can be amply divided between extra quantitative channels. And with the ability to synthesize DiLeu cost-effectively, on-demand, and in bulk, experiments of grand scope and scale are well within reach.
