Chemical Labeling Publication Library
Ongoing development has led to other viable dimethylated amino acid tags, alternative applications, and novel implementations.
Read more about DiLeu and its variants, including their use for protein, peptide, and metabolite quantification, and much more.

full text
Diazobutanone-assisted isobaric labelling of phospholipids and sulfated glycolipids enables multiplexed quantitative lipidomics using tandem mass spectrometry

full text
High-throughput relative quantification of fatty acids by 12-plex isobaric labeling and microchip capillary electrophoresis – Mass spectrometry

full text
11-Plex DiLeu Isobaric Labeling Enables Quantitative Assessment of Brain Region Protein Association Networks Impacted by the Gut Microbiome

full text
Recent Advances in Labeling-Based Quantitative Glycomics: From High-Throughput Quantification to Structural Elucidation

full text
12-Plex Isobaric Multiplex Labeling Reagents for Carbonyl-Containing Compound (SUGAR) Tag-Enabled High-Throughput Quantitative Glycomics

full text
sn-Position-Resolved Quantification of Aminophospholipids by Isotopic N, N-Dimethyl Leucine Labeling and High-Resolution Ion Mobility Mass Spectrometry

full text
CHRISTMAS: Chiral Pair Isobaric Labeling Strategy for Multiplexed Absolute Quantitation of Enantiomeric Amino Acids

full text
Cysteine Counting via Isotopic Chemical Labeling for Intact Mass Proteoform Identifications in Tissue

full text
DiLeu Isobaric Labeling Coupled with Limited Proteolysis Mass Spectrometry for High-Throughput Profiling of Protein Structural Changes in Alzheimer’s Disease

full text
Development of novel isobaric tags enables accurate and sensitive multiplexed proteomics using complementary ions

full text
DiLeu: Enhanced Isobaric N,N-Dimethyl Leucine Tagging Strategy for a Comprehensive Quantitative Glycoproteomic Analysis

full text
Novel Isobaric Tagging Reagent Enabled Multiplex Quantitative Glycoproteomics via Electron-Transfer/Higher-Energy Collisional Dissociation (EThcD) Mass Spectrometry

full text
Isotopic N,N-dimethyl leucine tags for absolute quantification of clustering and apolipoprotein E in Alzheimer’s disease

full text
The transcriptional elongation factor CTR9 demarcates PRC2-mediated H3K27me3 domains by altering PRC2 subtype equilibrium

full text
12-Plex DiLeu Isobaric Labeling Enabled High-Throughput Investigation of Citrullination Alterations in the DNA Damage Response

full text
Integrated Label-Free and 10-plex DiLeu Isobaric Tag Quantitative Methods for Profiling Changes in the Mouse Hypothalamic Neuropeptidome and Proteome: Assessment of the Impact of the Gut Microbiome

full text
Isobaric labeling strategy utilizing 4-plex N,N-dimethyl leucine (DiLeu) tags reveals proteomic changes induced by chemotherapy in cerebrospinal fluid of children with B-cell acute lymphoblastic leukemia

full text
Spatiotemporal proteomics reveals the molecular consequences of hormone treatment in a mouse model of lower urinary tract dysfunction

full text
In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure exacerbates urinary dysfunction in hormone-treated C57BL/6J mice…

full text
Proteomic modulation in the dorsal spinal cord following spinal cord stimulation therapy in an in vivo neuropathic pain model

full text
High-Resolution Enabled 5-plex Mass Defect-based N,N-Dimethyl Leucine Tags for Quantitative Proteomics

full text
A Strategy for Discovery and Verification of Candidate Biomarkers in Cerebrospinal Fluid of Preclinical Alzheimer’s Disease

full text
Metandem: An online software tool for mass spectrometry-basedisobaric labeling metabolomics

full text
Quantitative Proteomics for Analyses of Multiple Samples in Parallel with Chemical Perturbation

full text
Quantitative Proteomic Analysis of a Genetically Induced Prostate Inflammation Mouse Model via Custom 4-plex DiLeu Isobaric Labeling

full text
Further Multiplexing with Quantitative Proteomics Enabled by Mass Defect and High Resolution MS

full text