Ptc7p Dephosphorylates Select Mitochondrial Proteins to Enhance Metabolic Function


Collaborating Investigator/s

David Pagliarini (University of Wisconsin-Madison)



Mitochondrial phosphorylation is abundant and dynamic, yet its regulation and contribution to organellar function is poorly understood. To address this, we coupled quantitative phosphoproteomics with classic biochemistry to study the mitochondrial phosphatase Ptc7p. We found that Ptc7p deletion perturbs mitochondrial phosphorylation, partially inactivates citrate synthase, and decreases organellar function.