The role of COQ9 in COQ biosynthesis


Collaborating Investigator/s

David Pagliarini (The Morgridge Institute for Research)


This project necessitated discovery lipidomics analyses for profiling of global lipid changes.

The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic barriers in lipid biology. Here, we reveal that this process relies on custom lipid-binding properties of COQ9. Overall, our results provide a mechanism for how a lipid-binding protein might access, select, and deliver specific cargo from a membrane to promote biosynthesis.

The collected discovery lipidomics data of this project served to advance LipiDex, the Center’s discovery lipidomics software tool, and enhanced its utility for analysis of a different organismal lipidome that could be repeated in the future projects.