Genetic regulation of plasma lipid species and their association with metabolic phenotypes


Collaborating Investigator/s

Johan Auwerx (Ecole Polytechnique Fédérale de Lausanne)


To enable QTL mapping, an outstandingly large mouse cohort had to be characterized via quantitative lipidomics. The project’s focus on mitochondrial function required through characterization of low-abundance mitochondria-specific lipid species, such as cardiolipins, which was carried out in plasma to generate the most holistic view of the organism.

This project was a driver in the development of a high throughput quantitative lipidomics platform that was later built upon for the use in other studies.