Lipidomic characterization of the BXD mouse cohort


Collaborating Investigator/s

Johan Auwerx (Ecole Polytechnique Fédérale de Lausanne)


To enable QTL mapping, an outstandingly large mouse cohort had to be characterized via quantitative lipidomics. The project’s focus on mitochondrial function required through characterization of low-abundance mitochondria-specific lipid species, such as cardiolipins, in the most metabolically active tissue – liver.

This project drove development of the high throughput quantitative lipidomics platform that was later built upon for the use in other studies.