Multi-omic profiling of the mitoprotease knockout collection


Collaborating Investigator/s

Dave Pagliarini (The Morgridge Institute for Research)


In-depth characterization of the large yeast knockout collection required holistic assessment of the knockout phenotypes via muti-omic methodology.

This project extended the use of our multi-omic approach to a new organism, Saccharomyces cerevisiae, and challenged it by increasing the demands for the number of samples analyzed, all of which required adopting our sample preparation and quantitation methodologies to rapidly and reproducibly profile many unique lipidomes, metabolomes, and proteomes.