and Applications
DiLeu isobaric tags feature efficient and convenient amine-reactive chemistry for labeling proteins, peptides, and metabolites derived from a wide variety of biological samples and clinical specimens, ranging from tissue extracts to cerebrospinal fluid or urine. The versatility of DiLeu to label nearly any sample makes it ideal for studies of human disease and mammalian disease models that require compatible proteomic methods to quantify changes within several different types of biological samples, or across multiple experimental conditions, and the reagents can be produced at the scale appropriate for the needs of the study. Currently, research of pancreatic cancer, restenosis, lower urinary tract symptoms, and Alzheimer’s disease are all employing DiLeu and its variants for biological insight.