Biomarkers of Preclinical Alzheimer’s Disease in Cerebrospinal Fluid


Collaborating Investigator/s

Henrik Zetterberg (University of Gothenburg)


This project provided a real-world test bed for our emergent 5-plex isotopic N,N-dimethyl leucine (iDiLeu) technology that enables construction of a four-point internal calibration curve to determine the absolute amounts of target analytes.

The project successfully demonstrated the great utility of DiLeu tags for absolute quantitation of protein amounts in the most difficult sample types – clinical samples, paving the way for future uses of the reagent in other less complex situations.