17 Mar 2017

Instrumentation list

Instruments we use in our lab

17 Mar 2017
Our Equipment

Instruments we use in our lab

         
         

Mass Spectrometers (all Thermo Fisher Scientific)

Orbitrap Astral: Latest generation Orbitrap with Astral mass analyzer for high throughput, deep coverage, high sensitivity, and accurate quantitation. (2 systems)

Orbitrap Ascend Tribrid:  Latest generation, ETD and PTR-enabled quadrupole-Orbitrap-dual cell quadrupole linear ion trap hybrid system (Qq-OT-QLT). (2 systems)

Orbitrap Exploris 240: Quadrupole Orbitrap MS system for high data quality and depth of analysis.

Q Exactive UHMR: Ultra-High Mass Range (UHMR) quadrupole-Orbitrap hybrid system (Qq-OT) for native intact mass and top-down analysis. (2 systems)

LTQ Velos Dual Linear Ion Trap: ETD-enabled, dual-pressure linear ion trap mass spectrometer that has been modified to perform NETD and AI-ETD.

Q Exactive Focus Hybrid Quadrupole-Orbitrap: High-resolution accurate-mass quadrupole-Orbitrap hybrid system (Qq-OT) with restricted TopN capabilities.

ISQ Single Quadrupole GC/MS system: Single quadrupole system with Trace 1310 gas chromatograph and TriPlus RSH autosampler for robotic sample handling.

Modified LTQ Mass Spectrometer: Custom quadrupole linear ion trap system with a modified ETD reagent source.

         
         

Liquid Chromatography Systems (all Thermo Fisher Scientific)

Vanquish Neo UHPLC: All-in-one nano-, capillary-, and micro-flow LC for high-sensitivity LCMS workflows and low-flow applications. (5 systems)

Vanquish UHPLC: Latest generation binary pump (up to 1,500 MPa) equipped with split HT autosampler and column heater. (2 systems)

Dionex UltiMate 3000 nano UHPLC: Equipped with a RS autosampler. (2 systems)

Dionex UltiMate 3000 UHPLC: Normal-flow ultra-high-pressure liquid chromatography pump equipped with UV detectors, column heaters, and RS autosampler. One system is connected to a fraction collector. (5 systems)

         
         

Mass Spec Workflow 

TriVersa NanoMate (Advion): Automated ion source platform for high throughput infusion.

1260 Infinity II HPLC (Agilent Technologies): Normal-flow ultra-high-pressure liquid chromatography pump equipped with a column heater, a UV detector, and an automated fraction collector. Offline for preparative work.

Zip Chip (908 Devices): Autosampler for on-chip SPE proteomics and metabolomics analysis using a complete workflow.

Proteograph System (Seer): Automated plasma sample preparation system for mass spectrometry workflow.

STARlet (Hamilton): Programmable automated liquid handling system.

Fractionator (Basi): Refrigerated dual channel fraction collector.

         
         

Fabrication and Manufacturing 

Ultra-high-pressure column packing station (In-house made): Reinforced glass enclosure that houses ultra-high-pressure pump and fittings (up to 50,000 psi) connected to a packing slurry chamber and equipped with a microscopic camera.

P-2000 and P-1000 Micropipette Puller (Sutter Instruments): for fabrication of micropipettes, optical fiber probes, and nanospray tips.

Plasma Cleaner PDC-001-HP & PlasmaFlo PDC-FMG (Harrick): with supplemental gas mixing for contactless cleaning of sensitive surfaces and hydrophilic coating.

Tormach 1100M 4-axis CNC Mill: equipped with automatic tool changer, used for building custom parts and equipment.

Tormach PCNC 440 Benchtop Mill: designed for fabrication of small instrument components.

Tormach 15L Slant-PRO CNC Lathe: equipped with automatic collet closer and turret

Bambu Lab X1: CoreXY printer

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