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Software Highlight: LipidGenie

LipidGenie is one of many free and innovative resources offered by NCQBCS.

Lipid Genie is an interactive software that can facilitate lipid identification, provide evidence for gene function, and can reveal acyl-chain specificity for ABHD1 and ABHD2.

This open-sourced software is available free and online at lipidgenie.com.

Lipid Genie Logo. This logo depicts a magic lamp with a DNA helix inside, and a lipid structure exiting through the spout of the lamp.

3rd Annual North American Mass Spectrometry Summer School Registration Open

Join us for our third annual mass spectrometry summer school, which will be held in Madison, WI from June 15-18. We are proud to have assembled over a dozen world leading experts in mass spectrometry for this four-day course. Our goal is to provide our students, both from academia and industry, an engaging and inspiring program covering the latest in the application of mass spectrometry to omic analyses. Tutorial lectures range from mass analyzers to the basics of data analysis. Also planned are several hands-on workshops – aimed at both scientific and professional development. This program is made possible by generous funding from the National Science Foundation (Integrated Organismal Systems, Plant Genome Research Program, Grant No. 1546742) and the National Institutes of Health National Center for Quantitative Biology of Complex Systems (P41 GM108538). As such, there is no cost to participate.

Registration open through March 1, 2020: https://www.ncqbcs.com/resources/training/summer-school.

Please help us spread the word about this program by sharing the news with anyone who might have possible interest to participate.

See below for a list of expert instructors who will be leading the courses, as well as premium tutorial lectures and hands-on workshops that you can experience.

Thank you,
Josh Coon, Evgenia Shishkova, and Laura Van Toll (organizing committee)


Expert Instructors:

Scott McLuckey | Purdue University

Rachel Loo | University of California-Los Angeles

Joshua Coon | University of Wisconsin-Madison

Donald Hunt (invited) | University of Virginia

Shawnna Buttery | STAR Protocols

Jesper Velgaard Olsen | University of Copenhagen

Lingjun Li | University of Wisconsin-Madison

Jürgen Cox | Max Planck Institute of Biochemistry

Edward Huttlin | Harvard University

Susan Olesik | Ohio State University

Evgenia Shishkova | University of Wisconsin-Madison

Jessica Prenni | Colorado State University

Vicki Wysocki | Ohio State University

John Bowden | University of Florida

Tutorial Lectures:
Mass analyzers

Ionization

Tandem MS

Data acquisition

Quantification  

Experimental design

Separations  

PTMs

Metabolomics  

Top-down/Native MS

Lipidomics


Hands-on Workshops:
Mass analyzers

Spectral interpretation
Publishing and reviewing

Science writing

Science illustrations

Registration for the Annual Mass Spectrometry Summer School Opens Jan 8

Registration for the 3rd annual North American Mass Spectrometry Summer School is now open.

This free event, which will take place June 15-18, 2020 in Madison, Wisconsin will feature world-leading experts in Mass Spectrometry, who will deliver lectures and tutorials on both plant (NSF) and animal (NIH) mass spec applications. 

Program details and registration can be found on the NCQBCS website, located here:
https://www.ncqbcs.com/resources/training/summer-school.

Please help us spread the word about Mass Spec Summer School by telling your colleagues and friends who might benefit from attending. 

Registration for this opportunity closes on March 1.

Software Highlight: Morpheus

Morpheus, a custom search algorithm designed specifically for high-resolution tandem mass spectra, is one of many free softwares offered by NCQBCS.

Developed by the Coon Lab, Morpheus works specifically with high-mass accuracy data, and is superior to other similar programs, such as those originally designed for low-resolution MS/MS. For instance, compared to Mascot, Open Mass Spectrometry Search Algorithm (OMSSA) and Sequest, Morpheus can identify more spectra, peptides and proteins at a 1% false discovery rate. Morpheus is also 1.5-4.6 times faster than OMSSA.

Morpheus is free and open source under a permissive license.

The manuscript for Morpheus is available here, and the software can be downloaded here. Additionally, information on other software that the National Center for Quantitative Biology of Complex Systems offers can be found here.

Graphical abstract for the Morpheus manual, demonstrating the algorithm's matching capabilities 
Morpheus score =10.302, 10 matching products +30.2% matching abundance.

Registration for the 3rd Annual Mass Spec Summer School Opens in January

Registration for the NCQBCS third annual North American Mass Spectrometry Summer School will open January 2, 2020.

The NAMSS summer school is an exciting opportunity for burgeoning scientists to network and learn from leading mass spectrometry experts in both plant and animal applications.

The summer school will take place in Madison, WI from June 15-18. A variety of activities, such as lectures and workshops, will be held.

Additionally, as a summer school student, you will be able to:

Present a Poster
The poster session will be held Monday afternoon (June 15th) with prizes awarded to the top entries.

Give a Flash Talk
Flash talks will be scheduled throughout the week. They are 5-minute, one-slide presentations of your work, a research question you want input on, or something else of interest you would like to ask or share with the group. Prizes awarded to the top talks.

Future Technology Discussion
The event will include a discussion titled “Future Technology Needs”, where we want to hear your ideas of what technology is missing in the current research environment that would help advance your work. This could be techniques, protocols, instrumentation capability, etc. These can be big or small ideas, realistic or just a dream.

Join World-Leading Experts for Morning Coffee and Q&A
Sign up for a morning session where you bring your questions and get help from the experts. Sessions are limited to 15 people and we request you submit a question in advance so we can come prepared for the discussion.

Tweet Your Thoughts and Ideas
Join in via twitter during the sessions.

More information on the NAMSS 2020 summer school can be found here.

Software Highlight: Compass

The Coon OMSSA Proteomic Analysis Software Suite, or COMPASS, is one of many custom software and web-based data tools that NCQBCS offers in an effort to extend its expertise to the broader scientific community.

Compass is a free and open-source software pipeline designed around the Open Mass Spectrometry Search Algorithm. Compass aids in high-throughput analysis of proteomics data such as FASTA database creation, peptide-spectral matching, calculation of false discovery rates, and protein grouping, as well as spectral reduction, peptide quantitation via isobaric labeling (or without), and protein parsimony.

Furthermore Compass utilizes graphical user interfaces which work well with data files in original instrument vendor format, making it easy to use.

The manuscript for Compass is available here, and the software can be downloaded here. Additionally, information on other software that the National Center for Quantitative Biology of Complex Systems offers can be found here.

Graphical abstract from the COMPASS manual, demonstrating its uses as a database maker, dta generator, fdr optimizer, and protein herder.

2nd Summer School a Success

The 2nd Annual North American Mass Spectrometry Summer School, which took place from July 21-24 at the Wisconsin Institute for Discovery, was a success.

The event’s goal was to encourage and stimulate a community of scientists who are interested in mass spectrometry, plants and human health. This included tutorial and research lectures, workshops and a poster viewing session. Topics ranged from data analysis, chromatography and PTMs, to data integration, intellectual property and spectral interpretation, among others.

Featured speakers included Joshua Coon from the University of Wisconsin-Madison, Ulrike Kusebauch from the Institute for Systems Biology, Beatrix Ueberheide from the New York University School of Medicine, Lingjun Li from the University of Wisconsin-Madison, Judit Villen from the University of Washington, and Evan Williams from the University of California-Berkley, among many others.

Summer School was followed by the 11th Annual MaxQuant Summer School, which took place from July 24-26 in the same location. Students were able to attend one or both events.

Next year’s summer school will take place June 15-18.

For more information, visit https://www.ncqbcs.com/summer-school-2019/