Facts

Viewing posts from the Facts category

Software Highlight: Morpheus

Morpheus, a custom search algorithm designed specifically for high-resolution tandem mass spectra, is one of many free softwares offered by NCQBCS to the greater scientific community.

Developed by the Coon Lab, Morpheus works specifically with high-mass accuracy data, and is superior to other similar programs, such as those originally designed for low-resolution MS/MS. For instance, compared to Mascot, Open Mass Spectrometry Search Algorithm (OMSSA) and Sequest, Morpheus can identify more spectra, peptides and proteins at a 1% false discovery rate. Morpheus is also 1.5-4.6 times faster than OMSSA.

Morpheus is free and open source under a permissive license.

The manuscript for Morpheus is available here, and the software can be downloaded here. Additionally, information on other software that the National Center for Quantitative Biology of Complex Systems offers can be found here.

Registration for the 3rd Annual Mass Spec Summer School Opens in January

Registration for the NCQBCS third annual North American Mass Spectrometry Summer School will open January 2, 2020.

The NAMSS summer school is an exciting opportunity for burgeoning scientists to network and learn from leading mass spectrometry experts in both plant and animal applications.

The summer school will take place in Madison, WI from June 15-18. A variety of activities, such as lectures and workshops, will be held.

Additionally, as a summer school student, you will be able to:

Present a Poster
The poster session will be held Monday afternoon (June 15th) with prizes awarded to the top entries.

Give a Flash Talk
Flash talks will be scheduled throughout the week. They are 5-minute, one-slide presentations of your work, a research question you want input on, or something else of interest you would like to ask or share with the group. Prizes awarded to the top talks.

Future Technology Discussion
The event will include a discussion titled “Future Technology Needs”, where we want to hear your ideas of what technology is missing in the current research environment that would help advance your work. This could be techniques, protocols, instrumentation capability, etc. These can be big or small ideas, realistic or just a dream.

Join World-Leading Experts for Morning Coffee and Q&A
Sign up for a morning session where you bring your questions and get help from the experts. Sessions are limited to 15 people and we request you submit a question in advance so we can come prepared for the discussion.

Tweet Your Thoughts and Ideas
Join in via twitter during the sessions.

More information on the NAMSS 2020 summer school can be found here.

Software Highlight: Compass

The Coon OMSSA Proteomic Analysis Software Suite, or COMPASS, is one of many custom software and web-based data tools that NCQBCS offers in an effort to extend its expertise to the broader scientific community.

Compass is a free and open-source software pipeline designed around the Open Mass Spectrometry Search Algorithm. Compass aids in high-throughput analysis of proteomics data such as FASTA database creation, peptide-spectral matching, calculation of false discovery rates, and protein grouping, as well as spectral reduction, peptide quantitation via isobaric labeling (or without), and protein parsimony.

Furthermore Compass utilizes graphical user interfaces which work well with data files in original instrument vendor format, making it easy to use.

The manuscript for Compass is available here, and the software can be downloaded here. Additionally, information on other software that the National Center for Quantitative Biology of Complex Systems offers can be found here.