Understanding the role of CARM1-induced arginine methylation of PKM2


Collaborating Investigator/s

Wei Xu (University of Wisconsin-Madison)


The project required detection and quantification of a rare and low-abundance post-translational modification – arginine methylation. Here we established a methodology for indirect detection and quantification of arginine methylation using DiLeu tags, extending the utility of this quantitative technology to analyses of this rare PTM that could be repeated in the future.